A recent study published in the Journal of Medicine and Dentistry in which, among other findings, demonstrated that baclofen, a medication prescribed to patients with alcohol dependence, could be used as a treatment for spasticity after alcohol withdrawal.
The study, by researchers at the University of Miami and the University of California at San Diego, was published in the journal
JAMA DermatolIn this paper, Dr. Sarah K. Galson of the University of Miami and colleagues compared the effectiveness and safety of baclofen and a placebo in patients with alcohol dependence. The study was supported by the National Institute of Alcohol Abuse and Alcoholism and the National Institute of Mental Health (NIMH) and the National Institute of Alcohol Research.
Galson’s paper was co-authored by her research co-authors, Dr. Elizabeth T. Leucht of the University of Miami, and Dr. John E. McFarland of the University of California, San Diego. The research team consisted of:
Baclofen and alcohol withdrawal are treatments used to treat alcohol dependence and to help patients maintain abstinence.
“Baclofen is a medication that is often used to treat alcohol dependence,” Galson wrote in the Journal of Medicine and Dentistry. “Baclofen may also be used to reduce the need for alcohol. However, because the drug is not a controlled substance, it is often taken off-label for this purpose, so it is not FDA-approved for use.”
In a, the study was published in the Journal of the American Medical Association.
Baclofen, sold as Lioresal and Lioresal-X, was originally designed as an oral medication, but was found to interact poorly with other medications. As a result, the drug was not approved for use in the United States, and many patients stopped taking it.
A few years later, in 2006, the Food and Drug Administration (FDA) approved baclofen for the treatment of alcohol dependence. The FDA approval also led to baclofen being sold as an oral medication. In 2018, the FDA approved baclofen as a treatment for alcohol dependence. In 2019, the FDA approved it as an off-label treatment for alcohol dependence.
Baclofen, sold as Lioresal and Lioresal-X, was originally designed as an oral medication. However, due to the side effects of alcohol withdrawal, it was not FDA-approved for use in the United States. Instead, the drug was used off-label for this purpose, so it was sold as a prescription drug. It was prescribed for the treatment of alcohol dependence.
In the study, which was published in the Journal of the American Medical Association, researchers found that baclofen significantly increased the number of patients who stopped taking it after they stopped drinking.
Baclofen is a muscle relaxer and an antispastic agent used to treat muscle spasms, spasticity, and pain associated with various conditions, including:
Baclofen is not approved for the treatment of muscle spasticity or pain associated with spinal or cerebral injuries. Baclofen should only be used under the supervision of a medical professional.
The dosage of this medicine depends on the condition being treated, as well as other factors. It is important to take the medicine as directed. Your doctor will likely start you on the lowest dose to avoid potential side effects.
Your doctor may increase the dose of this medicine to find a patient who is suitable for this treatment. This may mean that you may not achieve the desired effect.
Your doctor may adjust the dosage of this medicine to find the dose that is right for you. They may increase or decrease your dose, depending on your response to the medicine. It is important to tell your doctor about all your medical history, especially if you are pregnant, breastfeeding, trying, or recently had surgery. Your doctor may also prescribe this medicine to help you decide what dose of medicine you should take. Do not take the medicine if you have not taken it for a year.
To be effective, your doctor will need to take this medicine on an empty stomach. You will need to drink plenty of water while on this medicine.
You can take this medicine with or without food. However, it is not recommended to take it more than once a day. Avoid skipping any doses of medicine in your dosage plan.
The effects of this medicine will typically start to subside within a few hours after you start taking the medication. However, you will still need to take it regularly for the effects to continue.
Take this medicine as directed by your doctor. Swallow it as a whole. Do not chew, crush, or break it. Baclofen tablets should be swallowed whole. Do not chew or crush tablets.
The most common side effects of this medicine include:
In rare cases, the side effects of this medicine may include:
In addition, some patients may also have an allergic reaction to this medicine. Symptoms of an allergic reaction include a rash, itching, swelling, dizziness, trouble breathing, and trouble swallowing.
Contact your doctor if you experience any of the following symptoms:
Contact a doctor or health care provider right away if any of these symptoms occur.
This medicine can be taken with or without food. Avoid taking the medicine with food.
This medicine is classified as a muscle relaxant.
It works by increasing blood flow to the spinal cord and brain to help you perform better in bed. This helps you and your doctor to manage your condition better.
This medicine belongs to a group of drugs known as central nervous system depressants. It works by relaxing muscles and increasing blood flow.
This medicine can be used alone or with other drugs to treat spasticity.
The muscle relaxant class of drugs include:
This class of drugs is not approved for the treatment of spasticity.
Baclofen Tablets 20 mg by Teva a muscle relaxer and an antispastic agent. Baclofen is used to treat muscle symptoms caused by multiple sclerosis, including spasm, pain, and stiffness. Baclofen may also be used for purposes not listed in this medication guide.
Each tablet, for oral administration, contains 20 mg baclofen, USP. In addition, each tablet contains the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, dibasic calcium phosphate dihydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate.
Baclofen tablets are useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity.
Patients should have reversible spasticity so that baclofen treatment will aid in restoring residual function. Baclofen tablets may also be of some value in patients with spinal cord injuries and other spinal cord diseases.
Baclofen tablets are not indicated in the treatment of skeletal muscle spasm resulting from rheumatic disorders.
The efficacy of baclofen in stroke, cerebral palsy, and Parkinson’s disease has not been established and, therefore, it is not recommended for these conditions.
Brand: Teva PharmaceuticalsSize: 100 TabletsStrength: 20 mgNDC: 00172-4097-60UPC: 301724097605
Buy Baclofen Tablets 20 mg by Teva used to treat muscle symptoms caused by multiple sclerosis at Mountainside Medical Equipment.
Buy Baclofen Tablets 20 mg by Teva used to treat muscle symptoms caused by multiple sclerosis at Mountainside Medical Equipmentbaclofen tabletsUSPIn addition, each tablet contains the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, dibasic calcium phosphate dihydrate, magnesium stearate, microcrystalline cellulose, silicon dioxide, lactose monohydrate, magnesium stearate, silicon dioxide, magnesium stearate, microcrystalline cellulose, cellulose one percentManufacturer Teva PharmaceuticalsSize: 100 TabletsManufacturer Quality
multiple sclerosisBaclofen
baclofen 20 mg/2.5 mL
20 mg/2.5 mL
Not available
BACLOFEN 20MG TABLET contains BACLOFEN which belongs to a group of medicines called baclofen medicines. It is used to manage muscle spasms caused due to muscleamples (tired muscles) caused due to muscleamples (muscle spasms). This medicine is also used to treat anxiety and panic caused due to mental diseases.
BACLOFEN 20MG TABLET is not recommended for use in patients with heart disease. It is recommended that you avoid the consumption of alcohol before taking BACLOFEN 20MG TABLET.
BACLOFEN 20MG TABLET should be used in accordance with your doctor’s prescription only because you have been told that the benefits of this medicine are not sufficient.
The most common side effects of BACLOFEN 20MG TABLET include voluntary numbness and weakness. However, these side effects are usually mild and subside as the body adjusts to the medicine. However, you may experience the following side effects: muscle pain, cramps, spasms, constipation, dizziness, weakness, numbness or weakness, rashes, and fainting. If these side effects persist or worsen, you should consult a doctor.
Before taking BACLOFEN 20MG TABLET, you should inform your doctor if you have ever had an allergic reaction to BACLOFEN 20MG TABLET, if: you have been prescribed BACLOFEN 20MG TABLET or any other medicines, if you have any of the symptoms of an allergic reaction in the past, how old do you were when you first notice your medicine, if you are pregnant or breastfeeding, if you have kidney problems, if you have diabetes, if you are fructose-uninghc ed, if you are pregnant, or if you have diabetes. You are taking this medicine during pregnancy or breastfeeding. BACLOFEN 20MG TABLET may cause diarrhea in people taking medicines called nitrates. If you experience diarrhea while taking BACLOFEN 20MG TABLET, inform your doctor right away.
You should know that not all products should be taken with BACLOFEN 20MG TABLET. If you choose to take BACLOFEN 20MG TABLET, your doctor may take special care when using the medicine, since the effects of the medicine are not fully known.BACLOFEN 20MG TABLET is not recommended for use in children or adolescents under 18 years of age. It is not intended for use in women. BACLOFEN 20MG TABLET is not expected to be recommended for use in children or adolescents under the age of 18 years. Consult your doctor before using BACLOFEN 20MG TABLET.
The most common side effects of BACLOFEN 20MG TABLET include the side effects are mild and subsided after the end of the treatment.
Common side effects of BACLOFEN 20MG TABLET are voluntary numbness and weakness. However, side effects are usually mild and subsided after the end of the treatment.You should know that not all products will be taken with BACLOFEN 20MG TABLET. If you choose to take BACLOFEN 20MG TABLET, your doctor may take special care when using the medicine when using the medicine because the effects of the medicine are not fully known.
The most common side effects of BACLOFEN 20MG TABLET are voluntary numbness and weakness.
Baclofen is an inhibitor of the muscle relaxant effect of gamma-aminobutyric acid (GABA). It is indicated for the relief of spasticity caused by multiple sclerosis and spinal cord injuries. It is also indicated in cases of cerebral palsy.
GABA is a neurotransmitter, a chemical, with multiple actions on the central nervous system. It has been shown to influence the motor, cognitive, and behavioral functions of the nervous system in animals, including the brain. The GABAergic system is the first-line regulator of the central nervous system, exerting an inhibitory effect on several brain functions. When GABA is released, it exerts an inhibitory action on nerve cells, which are responsible for producing and transmitting messages.
Baclofen is effective for the treatment of spasticity caused by multiple sclerosis, spinal cord injuries, cerebral palsy, and Parkinson’s disease. It can also be used as a part of the management of spasticity in patients with cerebral palsy.
The clinical studies for this study are summarized in Table.
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